Mississippi's region

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USA Today Up & Down Words clue · answer #1 in the chain · last seen October 22, 2026

Answer

DEEP

SOUTH

DEEP SOUTH · 9 letters · two-word phrase

About this clue

The Up & Down Words clue “Mississippi's region” has the answer DEEP SOUTH. It is answer #1 in the chain — in this puzzle, the second word of each answer becomes the first word of the next. See the full October 22, 2026 chain for all seven answers, or browse every Up & Down Words puzzle.

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